Andrographolide

Andrographolide ndi mankhwala opangidwa kuchokera ku zitsamba zomwe zimapezeka mwachilengedwe ku China.The therere ali kwambiri mbiri ntchito TCM zochizira chapamwamba kupuma thirakiti matenda ndi yotupa ndi matenda opatsirana.Andrographis paniculata idayambitsidwa ndikulimidwa ku Guangdong komanso kumwera kwa Fujian mzaka za 50s.Amagwiritsidwa ntchito pochiza matenda osiyanasiyana opatsirana komanso kulumidwa ndi njoka.M'zaka zaposachedwa, kulima, kupanga mankhwala, pharmacology ndi zachipatala za Andrographis paniculata zaphunziridwa ku China.Andrographis paniculata ndi mankhwala achi China omwe amagwiritsidwa ntchito kwambiri, omwe amatha kuchotsa kutentha ndi poizoni, kuziziritsa magazi komanso kutulutsa mpweya.Kuchipatala, izo zimagwiritsa ntchito zochizira matenda kupuma thirakiti, pachimake bacillary kamwazi, gastroenteritis, chimfine, malungo ndi matenda oopsa.Ndi kuwonjezeka kwa kugwiritsa ntchito maantibayotiki ndi zotsatira zoyipa, mawu akupanga mankhwala achi China okhala ndi antibacterial effect akukula.Andrographis paniculata, monga mankhwala achi China omwe ali ndi antibacterial effect, adalandira chidwi kwambiri ndi makampani opanga mankhwala.

Zomera za Andrographis paniculata zimadziwika kuti zimakhala ndi ntchito zosiyanasiyana zamankhwala.Andrographolide, gawo lalikulu la mankhwalawa limakhudzidwa ndi ntchito yake yamankhwala.Tidaphunzira njira zama cell ndi zolinga zomwe zimasinthidwa ndi chithandizo cha andrographolide mu khansa ya anthu ndi ma cell a chitetezo.Chithandizo cha Andrographolide chinalepheretsa kuchuluka kwa ma cell a chotupa, kuyimira mitundu yosiyanasiyana ya khansa.Gululi limagwira ntchito yolimbana ndi khansa pama cell a khansa pomangidwa mozungulira ma cell pagawo la G0/G1 kudzera pakulowetsa mapuloteni oletsa ma cell-cycle inhibitory protein p27 komanso kutsika kwa cyclin-dependent kinase 4 (CDK4).Immunostimulatory ntchito ya andrographolide umboni ndi kuchuluka kuchulukana lymphocytes ndi kupanga interleukin-2.Andrographolide imathandiziranso kupanga chotupa cha necrosis factor-alpha ndi mafotokozedwe a CD, zomwe zimapangitsa kuti ma lymphocyte achuluke polimbana ndi maselo a khansa, zomwe zitha kuthandizira pakuchita kwake kosalunjika.Zochita za mu vivo anticancer pagulu zimatsimikiziridwa motsutsana ndi B16F0 melanoma syngenic ndi HT-29 xenograft models.Zotsatirazi zikusonyeza kuti andrographolide ndi mankhwala osangalatsa a pharmacophore omwe ali ndi anticancer ndi immunomodulatory activities ndipo motero ali ndi mwayi wopangidwa ngati wothandizira khansa.